Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin

Heat-stable enterotoxin (ST<sub>a</sub>) produced by enterotoxigenic <i>E. coli</i> causes acute diarrhea and also can be used as a specific probe for colorectal cancer cells. ST<sub>a</sub> contains three intra-molecular disulfide bonds (C1–C4, C2–C5, and C3–C6 c...

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Main Authors: Shigeru Shimamoto, Mayu Fukutsuji, Toi Osumi, Masaya Goto, Hiroshi Toyoda, Yuji Hidaka
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-10-01
Series:Molecules
Assuntos:
disulfide
enterotoxin
folding
guanylyl cyclase
topological
Acceso en liña:https://www.mdpi.com/1420-3049/25/20/4798
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