CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However, the role that CD200R signaling plays during...

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Autores principales: Gabrielle Stack, Emma Jones, Morgan Marsden, Maria A Stacey, Robert J Snelgrove, Paul Lacaze, Laura C Jacques, Simone M Cuff, Richard J Stanton, Awen M Gallimore, Tracy Hussell, Gavin W G Wilkinson, Peter Ghazal, Philip R Taylor, Ian R Humphreys
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2015-02-01
Colección:PLoS Pathogens
Acceso en línea:https://doi.org/10.1371/journal.ppat.1004641
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