Role of Cystic Fibrosis Bronchial Epithelium in Neutrophil Chemotaxis

A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (CFTR) ion channel promotes dehydration of the airwa...

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Bibliographic Details
Main Authors: Giulio Cabrini, Alessandro Rimessi, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Paolo Pinton, Roberto Gambari
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
epithelium
lung
chemotaxis
neutrophil
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01438/full
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