Assessing the effect of genetic markers on drug immunogenicity from a mechanistic model-based approach

Abstract Background With the growth in use of biotherapic drugs in various medical fields, the occurrence of anti-drug antibodies represents nowadays a serious issue. This immune response against a drug can be due either to pre-existing antibodies or to the novel production of antibodies from B-cell...

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Main Authors: Julianne Duhazé, Miguel Caubet, Signe Hässler, Delphine Bachelet, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Aude Gleizes, Salima Hacein-Bey-Abina, Xavier Mariette, Marc Pallardy, Philippe Broët, on behalf of the ABIRISK Consortium
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2020-03-01
סדרה:BMC Medical Research Methodology
נושאים:
Genetic
Drug immunogenicity
Semi-continuous data
Two-part improper survival model
Semi-parametric
גישה מקוונת:http://link.springer.com/article/10.1186/s12874-020-00941-z
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