Osteoblasts mineralization and collagen matrix are conserved upon specific Col1a2 silencing

Classical osteogenesis imperfecta (OI) is an inherited rare brittle bone disease caused by dominant mutations in the COL1A1 or COL1A2 genes, encoding for the α chains of collagen type I. The definitive cure for the disease will require a gene therapy approach, aimed to correct or suppress the mutant...

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Main Authors: Silvia Maruelli, Roberta Besio, Julie Rousseau, Nadia Garibaldi, Jérôme Amiaud, Bénédicte Brulin, Pierre Layrolle, Virginie Escriou, Antonio Rossi, Valerie Trichet, Antonella Forlino
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020-05-01
Series:Matrix Biology Plus
Assuntos:
Collagen
Osteogenesis imperfecta
siRNA
Silencing
Gene therapy
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2590028520300090
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