Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs), and epithelial cells. Non-primates express one SP-A protein whereas humans express two: SP-A1 and SP-A2 with core intra...

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Hauptverfasser: Armen Nalian, Todd M. Umstead, Ching-Hui Yang, Patricia Silveyra, Neal J. Thomas, Joanna Floros, Francis X. McCormack, Zissis C. Chroneos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-11-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
alveolar macrophages
binding
lung
surfactant protein A
receptor
Online Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2019.02613/full
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