Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury

Atorvastatin, a lipid-lowering medication, provides neuroprotective effects, although the precise mechanisms of action remain unclear. Our previous studies confirmed activated autophagy following spinal cord injury, which was conducive to recovery of neurological functions. We hypothesized that ator...

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Główni autorzy: Shuang Gao, Zhong-ming Zhang, Zhao-liang Shen, Kai Gao, Liang Chang, Yue Guo, Zhuo Li, Wei Wang, Ai-mei Wang
Format: Artigo
Język:Inglês
Wydane: Wolters Kluwer Medknow Publications 2016-01-01
Seria:Neural Regeneration Research
Hasła przedmiotowe:
nerve regeneration; spinal cord injury; secondary injury; statins; atorvastatin; autophagy; Beclin-1; light chain 3B; neuroprotection; apoptosis; motor function recovery; neural regeneration
Dostęp online:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=977;epage=982;aulast=Gao
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