Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury

Atorvastatin, a lipid-lowering medication, provides neuroprotective effects, although the precise mechanisms of action remain unclear. Our previous studies confirmed activated autophagy following spinal cord injury, which was conducive to recovery of neurological functions. We hypothesized that ator...

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Main Authors: Shuang Gao, Zhong-ming Zhang, Zhao-liang Shen, Kai Gao, Liang Chang, Yue Guo, Zhuo Li, Wei Wang, Ai-mei Wang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Wolters Kluwer Medknow Publications 2016-01-01
Sraith:Neural Regeneration Research
Ábhair:
nerve regeneration; spinal cord injury; secondary injury; statins; atorvastatin; autophagy; Beclin-1; light chain 3B; neuroprotection; apoptosis; motor function recovery; neural regeneration
Rochtain Ar Líne:http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=977;epage=982;aulast=Gao
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