Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

Background: Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin’s participation in the pathophysiology of withdrawal s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jiqing Yang, Zunyue Zhang, Zhenrong Xie, Ling Bai, Pu Xiong, Fengrong Chen, Tailin Zhu, Qingyan Peng, Hongjin Wu, Yong Zhou, Yuru Ma, Yongjin Zhang, Minghui Chen, Jianyuan Gao, Weiwei Tian, Kai Shi, Yan Du, Yong Duan, Huawei Wang, Yu Xu, Yi-Qun Kuang, Mei Zhu, Juehua Yu, Kunhua Wang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2022-05-01
Cyfres:Biomedicine & Pharmacotherapy
Pynciau:
Methamphetamine
Withdrawal
Gut microbiota
Metformin
Inosine
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S0753332222002256
Tagiau: Ychwanegu Tag
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