Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice

Background: Metformin exhibits therapeutic potential in behavioural deficits induced by methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact psychiatric symptoms, but there is no direct evidence supporting metformin’s participation in the pathophysiology of withdrawal s...

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Hlavní autoři: Jiqing Yang, Zunyue Zhang, Zhenrong Xie, Ling Bai, Pu Xiong, Fengrong Chen, Tailin Zhu, Qingyan Peng, Hongjin Wu, Yong Zhou, Yuru Ma, Yongjin Zhang, Minghui Chen, Jianyuan Gao, Weiwei Tian, Kai Shi, Yan Du, Yong Duan, Huawei Wang, Yu Xu, Yi-Qun Kuang, Mei Zhu, Juehua Yu, Kunhua Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2022-05-01
Edice:Biomedicine & Pharmacotherapy
Témata:
Methamphetamine
Withdrawal
Gut microbiota
Metformin
Inosine
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0753332222002256
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