Seatbelts in CAR therapy: How Safe Are CARS?

T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to...

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Bibliographic Details
Main Authors: Kentaro Minagawa, Xiaoou Zhou, Shin Mineishi, Antonio Di Stasi
Format: Artigo
Language:Inglês
Published: MDPI AG 2015-05-01
Series:Pharmaceuticals
Subjects:
chimeric antigen receptor
suicide gene
safety switch
adoptive immunotherapy
cell therapy
Online Access:http://www.mdpi.com/1424-8247/8/2/230
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