Optimized Ellagic Acid–Ca Pectinate Floating Beads for Gastroprotection against Indomethacin-Induced Gastric Injury in Rats

A peptic ulcer is an alimentary tract injury that leads to a mucosal defect reaching the submucosa. This work aimed to optimize and maximize ellagic acid (EA) loading in Ca pectinate floating beads to maximize the release for 24 h. Three factors were selected: Ca pectinate concentration (X1, 1–3 w/v...

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Hauptverfasser: Nabil A. Alhakamy, Shaimaa M. Badr-Eldin, Osama A. A. Ahmed, Abdulrahman A. Halwani, Hibah M. Aldawsari, Mohamed A. El-Moselhy, Aliaa Anter, Sara S. Sharkawi, Muhammad H. Sultan, Osama A. A. Madkhali, Muhammed A. Bakhrebah, Mohammad N. Alomary, Wesam H. Abdulaal, Usama A. Fahmy
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-07-01
Schriftenreihe:Biomolecules
Schlagworte:
stomatitis
formulation
peptic ulcer
NSAIDs
factorial design
pharmacokinetics
Online Zugang:https://www.mdpi.com/2218-273X/10/7/1006
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