Effects of rhBMP-2-loaded hydroxyapatite granules/beta-tricalcium phosphate hydrogel (HA/β-TCP/hydrogel) composite on a rat model of caudal intervertebral fusion

Abstract The effects and inflammation-related side effects of bone morphogenetic protein (BMP)-2 on posterior lumbar interbody fusion are controversial. One of the potential causes for the inconsistent results is the uncontrolled release of BMP-2 from the collagen carrier. Therefore, BMP delivery sy...

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Main Authors: Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino, Shota Takenaka, Seiji Okada, Takashi Kaito
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2022-05-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-022-12082-y
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