CCR5 genotypes and progression to HIV disease in perinatally infected children

The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The...

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Bibliographic Details
Main Authors: Daniela Souza Araújo de Angelis, Wilton Santos Freire, Cláudio Sergio Pannuti, Regina Célia de Menezes Succi, Daisy Maria Machado
Format: Artigo
Language:Inglês
Published: Elsevier
Series:Brazilian Journal of Infectious Diseases
Subjects:
HIV-1
CCR5 co-receptor
HIV disease progression
perinatally infected children
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200004&lng=en&tlng=en
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