Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats

In the kidney, reabsorption via the epithelial sodium channel (ENaC) is involved in long-term blood pressure control. Previously we demonstrated that ENaC hyperactivity is associated with development of salt-sensitive (SS) hypertension in Dahl SS rats. AMP-activated kinase (AMPK), playing a role in...

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Bibliographic Details
Main Authors: Tengis S. Pavlov, Vladislav Levchenko, Daria V. Ilatovskaya, Hui Li, Oleg Palygin, Nuria M. Pastor-Soler, Kenneth R. Hallows, Alexander Staruschenko
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
hypertension
salt sensitivity
AMPK
metformin
AICAR
ENaC
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00227/full
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