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Biophysical and functional study of CRL5Ozz, a muscle specific ubiquitin ligase complex

Abstract Ozz, a member of the SOCS-box family of proteins, is the substrate-binding component of CRL5Ozz, a muscle-specific Cullin-RING ubiquitin ligase complex composed of Elongin B/C, Cullin 5 and Rbx1. CRL5Ozz targets for proteasomal degradation selected pools of substrates, including sarcolemma-...

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Main Authors: Yvan Campos, Amanda Nourse, Ajay Tanwar, Ravi Kalathur, Erik Bonten, Alessandra d’Azzo
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2022-05-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-022-10955-w
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