Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

In this report, we present the results of a single patient with optic neuropathy treated within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and is the largest ophthalmology stem cell study registered at the National Institutes o...

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Bibliographic Details
Main Authors:	Jeffrey N Weiss, Steven Levy, Alexis Malkin
Format:	Artigo
Language:	Inglês
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Neural Regeneration Research
Subjects:	microtubule axon kinesin-5 Eg5 regeneration monastrol molecular motor protein aging neurodegenerative disorders telomere shortening MSCs cellular therapy traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion blood brain barrier phage display peptide library nanocarrier targeting Schwann cells neurite outgrowth neuromuscular junction (NMJ) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression nerve regeneration bone marrow mesenchymal stem cells cerebral ischemia tail vein injection middle cerebral artery occlusion cell therapy neuroprotection brain injury neuroimaging ferumoxytol superparamagnetic iron oxide particles human adipose-derived stem cells intracerebral injection magnetic resonance imaging enhanced susceptibility-weighted angiography image modified neurological severity scores rats Prussian blue staining neural regeneration non-invasive brain stimulation transcranial magnetic stimulation neurotrophic factor brain-derived neurotrophic factor neuroplasticity hippocampus cognitive function curcumin neurons HIV-1 gp120 V3 loop plasticity HIV-associated neurocognitive disorders output/input curve long-term potentiation excitatory postsynaptic potential paired-pulse facilitation Ca 2+ synaptosome NSFC grants hydrogen sulfide cerebral ischemia/reperfusion injury P2X 7 receptor 2 3 5-triphenyl-2H-tetrazolium chloride staining animal model protection sodium hydrosulfide immunofluorescence NSFC grant γ-aminobutyric acid glial fibrillary acidic protein glutamic acid decarboxylase neurotoxicity weaning organ index cerebrum cortex glutamate p53 tumor suppressor gene family cerebral ischemia/reperfusion pyramidal neurons CA1 region delayed neuronal death immunohistochemistry western blotting spinal cord injury rapamycin Wnt/β-catenin signaling pathway apoptosis caspase-3 loss of neurons hydrogen-rich saline reactive oxygen species physiological saline oxidative stress Basso Beattie and Bresnahan score malondialdehyde superoxide dismutase calcitonin gene-related peptide peripheral nerve injury rabbits sciatic nerve injury autologous nerve repair polylactic glycolic acid conduit extracellular matrix gel grafting stress relaxation creep viscoelasticity histomorphology electrophysiology pain sense model dorsal root ganglion primary sensory neuron glycosylated membrane protein sialic acid cell electrophoresis electrophoresis velocity heat-hyperalgesia behavior hyperalgesia neuraminidase N-propionylmannosamine glycoengineering sciatic nerve peripheral nerve branching arborisation Thy1-YFP mouse stem cells optic nerve optic neuropathy ophthalmology bone marrow-derived stem cells blindness visual loss
Online Access:	http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=982;epage=988;aulast=Weiss
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Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

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