Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling

Aortic valve interstitial cells (VICs) constitute a heterogeneous population involved in the maintenance of unique valvular architecture, ensuring proper hemodynamic function but also engaged in valve degeneration. Recently, cells similar to telocytes/interstitial Cajal-like cells described in vario...

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Hauptverfasser: Grzegorz J. Lis, Andrzej Dubrowski, Maciej Lis, Bernard Solewski, Karolina Witkowska, Veronika Aleksandrovych, Ewa Jasek-Gajda, Mateusz K. Hołda, Krzysztof Gil, Jan A. Litwin
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2020-08-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
valve interstitial cells
calcification
CD34
PDGFRα
calcific aortic valve disease
Online Zugang:https://www.mdpi.com/1422-0067/21/17/6330
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