Ca2+/Calcineurin-Dependent Inactivation of Neuronal L-Type Ca2+ Channels Requires Priming by AKAP-Anchored Protein Kinase A

Within neurons, Ca2+-dependent inactivation (CDI) of voltage-gated L-type Ca2+ channels shapes cytoplasmic Ca2+ signals. CDI is initiated by Ca2+ binding to channel-associated calmodulin and subsequent Ca2+/calmodulin activation of the Ca2+-dependent phosphatase, calcineurin (CaN), which is targeted...

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Bibliographic Details
Main Authors: Philip J. Dittmer, Mark L. Dell’Acqua, William A. Sather
Format: Artigo
Language:Inglês
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003416
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