Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection

Pluripotent stem cells are being actively studied as a cell source for regenerating damaged liver. For long-term survival of engrafting cells in the body, not only do the cells have to execute liver-specific function but also withstand the physical strains and invading pathogens. The cellular innate...

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Hlavní autoři: Joseph Ignatius Irudayam, Deisy Contreras, Lindsay Spurka, Aparna Subramanian, Jenieke Allen, Songyang Ren, Vidhya Kanagavel, Quoclinh Nguyen, Arunachalam Ramaiah, Kalidas Ramamoorthy, Samuel W. French, Andrew S. Klein, Vincent Funari, Vaithilingaraja Arumugaswami
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015-09-01
Edice:Stem Cell Research
Témata:
Pluripotent stem cells
Endoderm
Hepatocytes
Hepatocyte-like cells
Differentiation
Interferon
Innate immunity
ISG
Interferon-stimulated genes
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1873506115001063
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