The Protective Effect of a Long-Acting and Multi-Target HM-3-Fc Fusion Protein in Rheumatoid Arthritis

Current treatment of rheumatoid arthritis (RA) is limited by relative shortage of treatment targets. HM-3 is a novel anti-RA polypeptide consisting of 18 amino acids with integrin αVβ3 and α5β1 as targets. Previous studies confirmed that HM-3 effectively inhibit...

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Hlavní autoři: Ruijing Huang, Jian Li, Yibo Wang, Lihua Zhang, Xiaohui Ma, Hongyu Wang, Wenlei Li, Xiaodan Cao, Hanmei Xu, Jialiang Hu
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2018-09-01
Edice:International Journal of Molecular Sciences
Témata:
rheumatoid arthritis
HM-3
Fc-domain of immunoglobulin G4
synovial angiogenesis
inflammatory response
TNF-α
half-life
pharmacodynamics
On-line přístup:http://www.mdpi.com/1422-0067/19/9/2683
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