DeepRepeat: direct quantification of short tandem repeats on signal data from nanopore sequencing

Abstract Despite recent improvements in basecalling accuracy, nanopore sequencing still has higher error rates on short-tandem repeats (STRs). Instead of using basecalled reads, we developed DeepRepeat which converts ionic current signals into red-green-blue channels, thus transforming the repeat de...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Li Fang, Qian Liu, Alex Mas Monteys, Pedro Gonzalez-Alegre, Beverly L. Davidson, Kai Wang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2022-04-01
Cyfres:Genome Biology
Pynciau:
Short tandem repeat
Nanopore sequencing
Deep learning
Telomeric repeat
Mynediad Ar-lein:https://doi.org/10.1186/s13059-022-02670-6
Tagiau: Ychwanegu Tag
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