Vδ2 T-Cells Kill ZIKV-Infected Cells by NKG2D-Mediated Cytotoxicity

An expansion of effector/activated Vδ2 T-cells was recently described in acute Zika virus (ZIKV)-infected patients, but their role in the protective immune response was not clarified. The aim of this study was to define the antiviral activity of Vδ2 T-cells against ZIKV-infected ce...

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Hauptverfasser: Eleonora Cimini, Alessandra Sacchi, Sara De Minicis, Veronica Bordoni, Rita Casetti, Germana Grassi, Francesca Colavita, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Maria Giovanna Desimio, Margherita Doria, Chiara Agrati
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2019-09-01
Schriftenreihe:Microorganisms
Schlagworte:
ZIKV
innate immunity
Vδ2 T-cells
antiviral activity
NKG2D
cytotoxicity
perforin
Online Zugang:https://www.mdpi.com/2076-2607/7/9/350
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