The immunodominant T cell epitopes of the mycolyl-transferases of the antigen 85 complex of M. tuberculosis.

The Ag85 complex is a 30-32 kD family of three proteins (Ag85A, Ag85B and Ag85C), which all three possess enzymatic mycolyl-transferase activity involved in the coupling of mycolic acids to the arabinogalactan of the cell wall and in the biogenesis of cord factor. By virtue of their strong potential...

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Bibliographic Details
Main Author: Kris eHuygen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Immunology
Subjects:
immunodominance
antigen 85
mycolyl transferase
Th1 helper T cell
promiscuous epitopes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00321/full
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