Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.

Misexpression of Polycomb repressive complex 1 (PRC1) components in human cells profoundly influences the onset of cellular senescence by modulating transcription of the INK4a tumor suppressor gene. Using tandem affinity purification, we find that CBX7 and CBX8, two Polycomb (Pc) homologs that repre...

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Autores principales: Goedele N Maertens, Selma El Messaoudi-Aubert, Tomas Racek, Julie K Stock, James Nicholls, Marc Rodriguez-Niedenführ, Jesus Gil, Gordon Peters
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2009-07-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC2713427?pdf=render
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