<i>FOXC2</i> Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation

<i>FOXC2</i> is a member of the human forkhead-box gene family and encodes a regulatory transcription factor. Mutations in <i>FOXC2</i> have been associated with lymphedema distichiasis (LD), an autosomal dominant disorder that primarily affects the limbs. Most patients also...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Daniela Tavian, Sara Missaglia, Sandro Michelini, Paolo Enrico Maltese, Elena Manara, Alvaro Mordente, Matteo Bertelli
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2020-07-01
Серии:International Journal of Molecular Sciences
Предметы:
lymphedema distichiasis
FOXC2
nuclear transcription factor
functional analysis
transactivation activity
cell death
Online-ссылка:https://www.mdpi.com/1422-0067/21/14/5112
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы