<i>FOXC2</i> Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation

<i>FOXC2</i> is a member of the human forkhead-box gene family and encodes a regulatory transcription factor. Mutations in <i>FOXC2</i> have been associated with lymphedema distichiasis (LD), an autosomal dominant disorder that primarily affects the limbs. Most patients also...

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Autori principali: Daniela Tavian, Sara Missaglia, Sandro Michelini, Paolo Enrico Maltese, Elena Manara, Alvaro Mordente, Matteo Bertelli
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-07-01
Serie:International Journal of Molecular Sciences
Soggetti:
lymphedema distichiasis
FOXC2
nuclear transcription factor
functional analysis
transactivation activity
cell death
Accesso online:https://www.mdpi.com/1422-0067/21/14/5112
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