The Significance of MMP-1 in EGFR-TKI–Resistant Lung Adenocarcinoma: Potential for Therapeutic Targeting

Epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR-TKI) resistance is one of the most important problems in lung cancer therapy. Lung adenocarcinoma with EGFR-TKI resistance was reported to have higher abilities of invasion and migration than cancers sensitive to EGFR-TKI, but the func...

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Autors principals: Ryoko Saito, Yasuhiro Miki, Naoya Ishida, Chihiro Inoue, Masayuki Kobayashi, Shuko Hata, Hisafumi Yamada-Okabe, Yoshinori Okada, Hironobu Sasano
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2018-02-01
Col·lecció:International Journal of Molecular Sciences
Matèries:
MMP-1
EGFR-TKI resistance
lung adenocarcinoma
mTOR
Accés en línia:http://www.mdpi.com/1422-0067/19/2/609
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