Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes

Haemanthamine (HAE) has been proven as a potential anticancer agent. However, the therapeutic use of this plant-origin alkaloid to date is limited due to the chemical instability and poorly water-soluble characteristics of the agent. To overcome these challenges, we developed novel amphiphilic elect...

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Главные авторы: Khan Viet Nguyen, Ivo Laidmäe, Karin Kogermann, Andres Lust, Andres Meos, Duc Viet Ho, Ain Raal, Jyrki Heinämäki, Hoai Thi Nguyen
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI AG 2019-09-01
Серии:Pharmaceutics
Предметы:
haemanthamine
plant-origin alkaloid
electrospinning
amphiphilic nanofibers
self-assembled liposomes
physical solid-state properties
drug release
Online-ссылка:https://www.mdpi.com/1999-4923/11/10/499
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