Towards discovery of inhibitors of the undecaprenyl-pyrophosphate phosphatase BacA by virtual high-throughput screening

Increasing resistance to common antibiotics is becoming a major challenge that requires the development of new antibacterial agents. Peptidoglycan is an essential heteropolymer of the bacterial envelope that ensures the integrity and shape of all bacteria and is also an important target for antibiot...

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Библиографические подробности
Главные авторы: Marko Jukič, Rodolphe Auger, Victor Folcher, Matic Proj, Hélène Barreteau, Stanislav Gobec, Thierry Touzé
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2022-01-01
Серии:Computational and Structural Biotechnology Journal
Предметы:
BacA
Undecaprenyl pyrophosphate phosphatase
Escherichia coli
Antibacterials
Antibacterial drug design
Binding site identification
Online-ссылка:http://www.sciencedirect.com/science/article/pii/S2001037022001660
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