Towards discovery of inhibitors of the undecaprenyl-pyrophosphate phosphatase BacA by virtual high-throughput screening

Increasing resistance to common antibiotics is becoming a major challenge that requires the development of new antibacterial agents. Peptidoglycan is an essential heteropolymer of the bacterial envelope that ensures the integrity and shape of all bacteria and is also an important target for antibiot...

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Main Authors: Marko Jukič, Rodolphe Auger, Victor Folcher, Matic Proj, Hélène Barreteau, Stanislav Gobec, Thierry Touzé
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-01-01
Serier:Computational and Structural Biotechnology Journal
Fag:
BacA
Undecaprenyl pyrophosphate phosphatase
Escherichia coli
Antibacterials
Antibacterial drug design
Binding site identification
Online adgang:http://www.sciencedirect.com/science/article/pii/S2001037022001660
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