7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss.

Augmenting BDNF/TrkB signaling has been demonstrated to be a promising strategy for reversing cognitive deficits in preclinical models of Alzheimer disease (AD). Although these studies highlight the potential of targeting BDNF/TrkB signaling, this strategy has not yet been tested in a model that dev...

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Main Authors: Nicholas A Castello, Michael H Nguyen, Jenny D Tran, David Cheng, Kim N Green, Frank M LaFerla
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2014-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC3948846?pdf=render
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