Analytical characterization of coformulated antibodies as combination therapy

When two therapeutic agents are combined in a single formulation, i.e., coformulated, the quality and safety of the individual agents must be preserved. Here we describe an approach to evaluate the quality attributes of two individual monoclonal antibodies (mAbs), designated mAb-A and mAb-B, in cofo...

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Main Authors: Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang, Methal Albarghouthi
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis Group 2020-01-01
Serija:mAbs
Teme:
Quality attributes
monoclonal antibody
combination therapy
coformulated antibodies
hydrophobic interaction chromatography
higher-order structure
Online dostop:https://www.tandfonline.com/doi/10.1080/19420862.2020.1738691
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