Analytical characterization of coformulated antibodies as combination therapy

When two therapeutic agents are combined in a single formulation, i.e., coformulated, the quality and safety of the individual agents must be preserved. Here we describe an approach to evaluate the quality attributes of two individual monoclonal antibodies (mAbs), designated mAb-A and mAb-B, in cofo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang, Methal Albarghouthi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis Group 2020-01-01
Cyfres:mAbs
Pynciau:
Quality attributes
monoclonal antibody
combination therapy
coformulated antibodies
hydrophobic interaction chromatography
higher-order structure
Mynediad Ar-lein:https://www.tandfonline.com/doi/10.1080/19420862.2020.1738691
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