Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain

In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process. In rat, two splicing events produce several isoforms of ADAR2, called ADAR2a, ADAR2b, ADAR2e, and ADAR2f, but...

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Main Authors: Alice Filippini, Daniela Bonini, Edoardo Giacopuzzi, Luca La Via, Fabrizio Gangemi, Marina Colombi, Alessandro Barbon
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2018-02-01
Series:Genes
Assuntos:
ADAR2
RNA editing
alternative splicing
neuron
Acceso en liña:http://www.mdpi.com/2073-4425/9/2/79
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