Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant

Abstract Despite the increased usage of post-transplant cyclophosphamide (PTCy) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), our knowledge of immune reconstitution post-allo-HSCT in the setting of PTCy is limited. Adequate immune reconstitution is the key to a successful transp...

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Main Authors: Chenchen Zhao, Matthew Bartock, Bei Jia, Neal Shah, David F. Claxton, Baldeep Wirk, Kevin L. Rakszawski, Myles S. Nickolich, Seema G. Naik, Witold B. Rybka, W Christopher C. Ehmann, Raymond J. Hohl, Jessica Valentin, Michelle Bernas-Peterson, Emily M. Gerber, Michele Zimmerman, Joseph A. Mierski, Shin Mineishi, Hong Zheng
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2022-05-01
Series:Journal of Hematology & Oncology
Assuntos:
PTCy
T cell
Immune reconstitution
PD-1
Allo-HSCT
Acceso en liña:https://doi.org/10.1186/s13045-022-01287-3
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