Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade. Separating the effects of disease from medication is challenging due to the lack of a proper placebo-group. To address this, we conduct...

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Main Authors: Helle G. Andersen, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Bjørn H. Ebdrup
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020-05-01
叢編:Frontiers in Neuroscience
主題:
schizophrenia
dopamine receptor
first-episode antipsychotic-naïve
striatum
SPECT
sMRI
在線閱讀:https://www.frontiersin.org/article/10.3389/fnins.2020.00484/full
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