Towards Strain-Level Complexity: Sequencing Depth Required for Comprehensive Single-Nucleotide Polymorphism Analysis of the Human Gut Microbiome

Intestinal bacteria strains play crucial roles in maintaining host health. Researchers have increasingly recognized the importance of strain-level analysis in metagenomic studies. Many analysis tools and several cutting-edge sequencing techniques like single cell sequencing have been proposed to dec...

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Main Authors: Pu Liu, Shuofeng Hu, Zhen He, Chao Feng, Guohua Dong, Sijing An, Runyan Liu, Fang Xu, Yaowen Chen, Xiaomin Ying
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Assuntos:
gut microbiota
strain level
SNP
metagenomic sequencing
sequencing depth
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fmicb.2022.828254/full
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