Hepatotoxicity of the Major Anthraquinones Derived From Polygoni Multiflori Radix Based on Bile Acid Homeostasis

Polygoni Multiflori Radix (PMR), the dried root of Polygonum Multiflorum Thunb., has been widely used as traditional Chinese medicines in clinical practice for centuries. However, the frequently reported hepatotoxic adverse effects hindered its safe use in clinical practice. This study aims to explo...

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Hauptverfasser: Li Kang, Dan Li, Xin Jiang, Yao Zhang, Minhong Pan, Yixin Hu, Luqin Si, Yongjun Zhang, Jiangeng Huang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Pharmacology
Schlagworte:
Polygoni Multiflori Radix
anthraquinones
bile acids
homeostasis
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Online Zugang:https://www.frontiersin.org/articles/10.3389/fphar.2022.878817/full
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