Trajectory and Functional Analysis of PD‐1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing

Abstract The spatial heterogeneity of immune microenvironment in hepatocellular carcinoma (HCC) remains elusive. Here, a single‐cell study involving 17 432 600 immune cells of 39 matched HCC (T), nontumor (N), and leading‐edge (L) specimens by mass cytometry is conducted. The tumor‐associated CD4/CD...

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Autori principali: Bo Zheng, Dongfang Wang, Xinyao Qiu, Guijuan Luo, Tong Wu, Shuai Yang, Zhixuan Li, Yanjing Zhu, Shan Wang, Rui Wu, Chengjun Sui, Ziqi Gu, Siyun Shen, Seogsong Jeong, Xuan Wu, Jin Gu, Hongyang Wang, Lei Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2020-07-01
Serie:Advanced Science
Soggetti:
double positive T cells
liver cancer
mass cytometry
single‐cell sequencing
tumor microenvironment
Accesso online:https://doi.org/10.1002/advs.202000224
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