Conformational Flexibility in the CD81-Binding Site of the Hepatitis C Virus Glycoprotein E2

Numerous antibodies have been described that potently neutralize a broad range of hepatitis C virus (HCV) isolates and the majority of these antibodies target the binding site for the cellular receptor CD81 within the major HCV glycoprotein E2. A detailed understanding of the major antigenic determi...

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Bibliografiska uppgifter
Huvudupphovsmän: Luisa J. Ströh, Kumar Nagarathinam, Thomas Krey
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018-06-01
Serie:Frontiers in Immunology
Ämnen:
hepatitis C virus
glycoprotein E2
neutralizing antibodies
conformational flexibility
immunoglobulin-like domain
CD81-binding site
Länkar:https://www.frontiersin.org/article/10.3389/fimmu.2018.01396/full
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