Auto-segmentation and time-dependent systematic analysis of mesoscale cellular structure in β-cells during insulin secretion.

The mesoscale description of the subcellular organization informs about cellular mechanisms in disease state. However, applications of soft X-ray tomography (SXT), an important approach for characterizing organelle organization, are limited by labor-intensive manual segmentation. Here we report a pi...

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Main Authors: Angdi Li, Xiangyi Zhang, Jitin Singla, Kate White, Valentina Loconte, Chuanyang Hu, Chuyu Zhang, Shuailin Li, Weimin Li, John Paul Francis, Chenxi Wang, Andrej Sali, Liping Sun, Xuming He, Raymond C Stevens
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2022-01-01
Serier:PLoS ONE
Online adgang:https://doi.org/10.1371/journal.pone.0265567
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