Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors

Triapine, the most studied α-N-heterocyclic thiosemicarbazone, revealed potent activity against advanced leukemia, but was ineffective against a variety of solid tumors. Moreover, methemoglobinemia, which is a side effect of triapine administration, may limits all clinical application. To enhance an...

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Bibliografiska uppgifter
Huvudupphovsmän: Nenad R. Filipović, Snežana K. Bjelogrlić, Sveva Pelliccia, Vesna B. Jovanović, Milan Kojić, Milan Senćanski, Giuseppe La Regina, Romano Silvestri, Christian D. Muller, Tamara R. Todorović
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020-01-01
Serie:Arabian Journal of Chemistry
Länkar:http://www.sciencedirect.com/science/article/pii/S1878535217302320
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