Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer’s Disease Through the PINK1/Parkin Pathway

The accumulation of abnormal aggregation of amyloid-β plaques is one of the most distinguishing pathologies of Alzheimer’s disease (AD) and is highly toxic to neurons. Exosomes have demonstrated great potential for AD therapy. However, the impact and underlying mechanism of M2 microglia-derived exos...

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Huvudupphovsmän: Nan Li, Jun Shu, Xiaoyan Yang, Wenshi Wei, Aijuan Yan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2022-04-01
Serie:Frontiers in Cellular Neuroscience
Ämnen:
M2 microglia cells
mitophagy
exosomes
Alzheimer’s disease
Aβ treatment
PINK1/Parkin pathway
Länkar:https://www.frontiersin.org/articles/10.3389/fncel.2022.874102/full
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