Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging

Aging associated DNA hypomethylation of LINE-1 and Alu retroelements may be a crucial determinant of loss of genomic integrity, deterioration and cancer. In peripheral blood LINE-1 hypomethylation has been reported to increase during aging, but other studies did not observe significant changes. We h...

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Main Authors: Lars Erichsen, Agnes Beermann, Marcos J. Arauzo-Bravo, Mohamed Hassan, Mohamed A. Dkhil, Saleh Al-Quraishy, Taghreed A. Hafiz, Johannes C. Fischer, Simeon Santourlidis
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018-09-01
Serier:Saudi Journal of Biological Sciences
Online adgang:http://www.sciencedirect.com/science/article/pii/S1319562X18300408
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