No Cytotoxic and Inflammatory Effects of Empagliflozin and Dapagliflozin on Primary Renal Proximal Tubular Epithelial Cells under Diabetic Conditions In Vitro

Gliflozins are inhibitors of the renal proximal tubular sodium-glucose co-transporter-2 (SGLT-2), that inhibit reabsorption of urinary glucose and they are able to reduce hyperglycemia in patients with type 2 diabetes. A renoprotective function of gliflozins has been proven in diabetic nephropathy,...

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Main Authors: Patrick C. Baer, Benjamin Koch, Janina Freitag, Ralf Schubert, Helmut Geiger
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-01-01
Serier:International Journal of Molecular Sciences
Fag:
renal tubular cells
epithelial cells
proximal tubule
cytotoxicity
injury
inflammation
empagliflozin
dapagliflozin
kidney
Online adgang:https://www.mdpi.com/1422-0067/21/2/391
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