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Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

BACKGROUND:Adenosine is generated in response to cellular stress and damage and is elevated in the lungs of patients with chronic lung disease. Adenosine signaling through its cell surface receptors serves as an amplifier of chronic lung disorders, suggesting adenosine-based therapeutics may be bene...

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Main Authors: Yang Zhou, Jayasimha N Murthy, Dewan Zeng, Luiz Belardinelli, Michael R Blackburn
格式: Artigo
語言:Inglês
出版: Public Library of Science (PLoS) 2010-02-01
叢編:PLoS ONE
在線閱讀:http://europepmc.org/articles/PMC2821921?pdf=render
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