Synergistic Antibiofilm Effects of Pseudolaric Acid A Combined with Fluconazole against Candida albicans via Inhibition of Adhesion and Yeast-To-Hypha Transition

ABSTRACT Candida albicans biofilms are resistant to several clinical antifungal agents. Thus, it is necessary to develop new antibiofilm intervention measures. Pseudolaric acid A (PAA), a diterpenoid mainly derived from the pine bark of Pseudolarix kaempferi, has been reported to have an inhibitory...

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Hauptverfasser: Bin Zhu, Zhen Li, Hongmei Yin, Jun Hu, Yingjun Xue, Guanyi Zhang, Xin Zheng, Weiqin Chen, Xiaobo Hu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2022-04-01
Schriftenreihe:Microbiology Spectrum
Schlagworte:
Candida albicans
antibiofilm
fluconazole
pseudolaric acid A
resistance
synergism
Online Zugang:https://journals.asm.org/doi/10.1128/spectrum.01478-21
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