Ileal antimicrobial peptide expression is dysregulated in old age

Abstract In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal small intestine of aged mice. Our results show that old mice have reduced transcript l...

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Bibliographic Details
Main Authors: Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran, Alfredo Menendez
Format: Artigo
Language:Inglês
Published: BMC 2017-08-01
Series:Immunity & Ageing
Subjects:
Intestinal antimicrobial peptides
Aging
Microbiota
Ileum
Paneth cells
Goblet cells
Online Access:http://link.springer.com/article/10.1186/s12979-017-0101-8
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