CaMKIIα may modulate fentanyl-induced hyperalgesia via a CeLC-PAG-RVM-spinal cord descending facilitative pain pathway in rats.

Each of the lateral capsular division of central nucleus of amygdala(CeLC), periaqueductal gray (PAG), rostral ventromedial medulla(RVM) and spinal cord has been proved to contribute to the development of opioid-induced hyperalgesia(OIH). Especially, Ca2+/calmodulin-dependent protein kinase IIα (CaM...

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Bibliografiske detaljer
Main Authors: Zhen Li, Pingping Yin, Jian Chen, Shenglan Jin, Jieqiong Liu, Fang Luo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2017-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC5425219?pdf=render
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